There are several types of MS, and the kind you have may be one thing that determines not only whether you die of MS-related causes, but how long you might live once you’re diagnosed. MS and its complications are the cause of death for about half the people diagnosed with the disease. That 7.5-year difference is similar to what other researchers have found recently. The study found that people with MS lived to be 75.9 years old, on average, compared to 83.4 years old for those without. In a large 2015 study published in the journal Neurology, scientists compared 5,797 people who had MS with 28,807 people who didn’t but who did have things in common like age and location. Over the years, researchers have consistently found that MS, which damages the coating that protects your nerves, can also shorten your lifespan. And while better treatments appear to deserve much of the credit, there’s also plenty you can do to ensure that you live long and well. While it’s true that the average life expectancy is somewhat shorter for people with MS than for others who don’t have the condition, the gap has shrunk dramatically in recent years. Epub 2017 Dec 30.If you have multiple sclerosis (MS), a question may lurk in the back of your mind: Will this disease take years off my life? The answer is a mixed bag, experts say. ‘Leukodystrophy-like’ phenotype in children with myelin oligodendrocyte glycoprotein antibody-associated disease. (10) Hacohen Y, Rossor T, Mankad K, et al. Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in patients with optic neuritis and seizures. (9) Gutman JM, Kupersmith M, Galetta S, Kister I. Clinical spectrum and prognostic value of CNS MOG autoimmunity in adults: The MOGADOR study. (8) Cobo-Calvo A, Ruiz A, Maillart E, et al. Antibodies to MOG and AQP4 in children with neuromyelitis optica and limited forms of the disease. (5) Lechner C, Baumann M, Hennes EM, et al. Defining distinct features of anti-MOG antibody associated central nervous system demyelination. (4) Weber MS, Derfuss T, Metz I, Brück W. Comparison of myelin oligodendrocyte glycoprotein (MOG)-antibody disease and AQP4-IgG-positive neuromyelitis optica spectrum disorder (NMOSD) when they co-exist with anti-NMDA (N-methyl-D-aspartate) receptor encephalitis. 10 Leukodystrophies are genetic rare diseases that affect the central nervous system by disrupting myelination. One study described symptoms and MRI findings of MOG antibody disease in children under the age of 7 that were similar to leukodystrophies. 1 NMDA receptor encephalitis is an autoimmune encephalitis that can cause psychosis, issues with memory and language, and seizures. MOG antibody disease can also occur in relation to another condition called anti-N-methyl-D-aspartate (NMDA) receptor encephalitis. When a relapse occurs, the diagnosis of MOGAD is confirmed. In some, the MOG antibody persists, and relapses may occur. In many kids, the MOG antibody disappears within 1 year, and relapses do not occur. 4Ĭhildren can be found to have the MOG antibody in the setting of ADEM however, a positive MOG antibody test in the setting of ADEM does not necessarily imply a course of MOGAD. Those with MOG antibody disease are more likely to have both optic nerves affected at the same time, and if the symptoms are in only one eye, the other optic nerve may show subclinical atrophy. Paraparesis (weakness) of a limb or limbs.Paralysis (no motor function) of a limb or limbs.Loss or blurring of vision in one or both eyes.MOG antibody disease preferentially causes inflammation in the optic nerve, 8 but can also cause inflammation in the spinal cord, brain, and brainstem. 2022 Rare Neuroimmune Disorders Symposium.COVID-19 and Rare Neuroimmune Disorders.
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